• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文OA文献 >Circadian variation in the effects of aldosterone blockade on heart rate variability and QT dispersion in congestive heart failure
【2h】

Circadian variation in the effects of aldosterone blockade on heart rate variability and QT dispersion in congestive heart failure

机译：醛固酮阻滞对充血性心力衰竭心率变异性和QT离散度影响的昼夜变化

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVESThe study was designed to comprehensively evaluate the circadian effects of aldosterone blockade on autonomic tone and QT dispersion in chronic heart failure (CHF).BACKGROUNDSpironolactone therapy given in addition to angiotensin-converting enzyme inhibitors improved survival in CHF, but the mechanism of its benefit is uncertain. Experimental evidence suggests that aldosterone may have detrimental effects on the autonomic nervous system, especially during the morning hours.METHODSTwenty-eight patients with New York Heart Association class II to IV CHF received spironolactone 50 mg daily and placebo for four weeks each in a double-blind crossover fashion. After each treatment phase, a full circadian assessment was undertaken of spironolactone’s autonomic effects. The assessment included monitoring heart rate, QT dispersion, continuous Holter recordings, heart rate variability (HRV) and norepinephrine kinetics.RESULTSSpironolactone significantly reduced all indices of QT dispersion. The reductions in QTcmax, QTd and QTcd were greatest at 6 am. In addition, spironolactone had favorable autonomic effects, which were limited to the morning (6–10 am), including heart rate reduction and an improvement in HRV.CONCLUSIONSSpironolactone reduced heart rate and improved HRV and QT dispersion in CHF. Its effects were particularly prominent during the morning hours.
机译：目的本研究旨在全面评估醛固酮拮抗剂对慢性心力衰竭（CHF）中自主神经张力和QT离散度的昼夜节律作用。背景螺内酯除血管紧张素转化酶抑制剂外还可以改善CHF的生存率，但其获益机制是不确定。实验证据表明，醛固酮可能会对植物神经系统产生不利影响，特别是在早晨。方法28名患有纽约心脏协会II至IV级CHF的患者每天接受50 mg螺内酯和安慰剂治疗，两次服用两次。盲目的交叉时尚。在每个治疗阶段之后，对螺内酯的植物神经功能进行了完整的昼夜节律评估。评估包括监测心率，QT离散度，连续动态心电图记录，心率变异性（HRV）和去甲肾上腺素动力学。结果丙内酯显着降低了所有QT离散度指标。 QTcmax，QTd和QTcd的下降在上午6点最大。此外，螺内酯具有良好的自主神经作用，仅限于早晨（上午6-10点），包括降低心率和改善HRV。结论螺内酯可以降低心律，并改善CHF中的HRV和QT离散度。在早晨，其效果尤为突出。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号